What is Low Level Light Therapy (LLLT)? Also Known as Photobiomodulation Therapy (PBMT), Low Level Laser Therapy, Infrared Light Therapy, Cold Laser Therapy, Low Intensity Light Therapy & Soft Laser

Therapy, all use light to accelerate, trigger or optimize a variety of body processes. How does it work?

Low level light therapy is a method of using light waves at various wavelengths, including infrared light, to treat a variety of conditions.

Low level light therapy (LLLT), also known as phototherapy or a variety of names, has been used for thousands of years by Ancient Indians and Greeks, who used different colors of glass to change the light spectrum projected onto an object.

Photo by T. Selin Erkan on Unsplash

Image 1. Ancient Greece

We know that the sun stimulates melanocytes and darkens skin pigment. In the absence of light, the circadian rhythm initiates the day:night cycle through melatonin. Other names include cold laser therapy, low-intensity light therapy, and soft laser therapy.

In 1923, Russian scientist Alexander Gurwitsch discovered that extremely low levels of ultraviolet light were emitted from onions. In the last 15 years, there are over 5,000 published articles showing various physiologic effects of LLLT such as stimulation of natural body responses.

The Visible Light Spectrum

Figure 1. The Visible Light Spectrum. The scale of light is in wavelength nanometers, where one nanometer is 10-9 m, or one billionth of a meter. Visible light is 400 – 700 nm.  Visible light has no light waves that are red.

In contrast to visible light having no red wavelengths, LLLT that achieves biological effects is in the spectrum of red, mid-infrared, and near-infrared light, usually at 100 – 600 nm wavelength.

Figure 2. The Ultraviolet Light Spectrum. UV-A is 320-400 nm; UV-B is 290 – 320 nm, and UV-C is less than 290 nm. The photoelectric effect is seen with light absorption, electromagnetic radiation, and electron emission as waves of electromagnetic field go through space, carrying energy.

The Effects of LLLT

At a cellular level, LLLT increases metabolic activity, improves nutrient transport across the cell membrane, activates cytochrome IV and cytochrome c oxidase (1). In mitochondria, LLLT improves the production and efficiency of ATP (adenosine triphosphate) generation. These optimize waste removal, nutrient absorption, and tissue repair. Mitochondrial melatonin increases, decreasing oxidative stress and free radical/DNA damage.

Systemic effects occur via up-regulation of anti-inflammatory and down-regulation of pro-inflammatory cytokines (2). White blood cells migrate to wounds, increasing angiogenesis and collagen formation (3). Johnstone et al surmise that LLLT at a distal body site can stimulate neuroregneration in the brain (4).

LLLT improves healing via tissue granulation, improves circulation and collagen production, boosts immunity, stimulates stem cells from bone marrow to navigate to damaged areas then release BDNF which in turn optimizes nerve function and survival (5), exerts a hermetic effect as an adaptive or positive stressor, and improves neurodegenerative disorders.

That DNA emits light has been proven. For example, the oxidative stress of human skin can be evaluated by imaging ultraweak photon emission (6). In diabetic neuropathy, LLLT has a stimulating effect on the microcirculation and tissue repair.

Frequencies and Photobiomodulation (PBM).

Different frequencies lead to different body effects. Adding pulsed width modulation provides even more optimized light therapy. Because light can be flashed at different speeds, as in turning a light on an off at different speeds, this pulse can be quite significant in determining how the light is received and utilized by cells. Some devices may pulse across 1-5 frequencies; others utilize 46 different frequencies spread across 26 different protocols, like Life Light (Figure 4) or Firefly (Figure 5):

Figure 4. Life Light Properties.

Figure 4. The Firefly. Stimulating light. The Firefly has stimulating light in the mixed-spectrum blue, red, and 850 and 940 nm far infrared light. In particular, the blue light has been shown to stimulate lymph nodes, promoting skin injury like burns, contusions, and cuts. Penetrating power. Output leads to more permeating depth, with deep tissue targeting up to 8 inches depth, so that more photon energy is transmitted to cells, leading to a reduction in the need for prolonged or repetitive treatments.

List of Conditions Showing Improvement After Firefly LLLT Wand by Bales Photonics

Responsive conditions that have been reported include":

Age-related macular degeneration

Alzheimer’s Disease

Angina pectoris

Arthritis

Autoimmune Disease

Back pain and sciatica

Bell’s Palsy

Carpal tunnel syndrome

Cervical disc

Chronic pain

Congestive heart failure

COVID lung symptoms

Dementia

Diabetes complications like neuropathy

Erectile dysfunction

Failed back syndrome

Familial amylotropic lateral sclerosis (FALS)

Fibromyalgia

Frontotemporal dementia (7)

Fungal infection

Generalized anxiety disorder

Gut issues or parasites

Headache

Heart attack

Hypothyroidism

Inflammation

Irritable bowel syndrome (IBS)

Knee pain

Lung: post-COVID lung congestion

Lyme disease

Lymphatic drainage

Major depression

Menstrual cramps

MRSA

Multiple sclerosis

Neck pain

Neurocognitive Dysfunction

Neuropathy

Osteoarthritis

Pain

Parkinson’s Disease

Pinched nerve

Plantar fasciitis

Prostate

PTSD

RSD/CRPS

Sciatica

Spinal injury

Stroke

Temporo-Mandibular Joint (TMJ) pain

Tennis elbow

Thoracic Outlet Syndrome

Thoracic pain

Tinnitus

TMJ

Traumatic brain injury (TBI) (3)

Spinal cord injury

Stroke or cerebrovascular accident (CVA)

Wound healing

The mechanism of neuroprotection includes ATP and reactive oxygen species synthesis, the latter or which induces neurogenesis (8).

Two Bioelectric Tests: Bioelectric imaging captures and confirms the tissue response to therapy. Patients can undergo bioelectric scanning and bipulsar waves over different regions, revealing the body’s response in a visual image that shows changes in the bioelectric field around the body.

If you have exhausted other means of healing an ailment, consider LLLT. Stay tuned as I attend with Dr. Len Saputo next week and observe LLLT in action, with the best of the best.

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REFERENCES

1. Rojas, J.C., & Gonzalez-Lima, F. (2011). Low-level light therapy of the eye and brain. Eye and Brain, 3, 49–67.

2. Muili, K.A. et al. (2012). Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by photobiomodulation induced by 670 nm light. PLoS ONE, 7, e30655.

3. Chung, H. et al. (2012). The Nuts and Bolts of Low-level Laser (Light) Therapy. Annals of Biomedical Engineering, 40(2), 516-533.gma.

4. Johnstone, D.M. et al. (2015). Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Frontiers in Neuroscience, 9, 500. doi: 10.3389/fnins.2015.00500.

5. Hou, S.T. et al. (2008). Permissive and Repulsive Cues and Signaling Pathways of Axonal Outgrowth and Regeneration. International Review of Cell and Molecular Biology, 267, 121-181.

6. Niggli, H.J., Applegate, L.A. (2003). Biophotons: Ultraweak Photons in Cells. In: Popp, FA., Beloussov, L. (eds) Integrative Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0373-4_11.

7. Purushothuman, S. et al. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61– 70.

8. Rojas, J.C., & Gonzalez-Lima, F. (2011). Low-level light therapy of the eye and brain. Eye and Brain, 3, 49–67.

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